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Alli Capsule. Alli Capsule is a weight loss medication that contains the active ingredient orlistat. It is available over-the-counter and is the only FDA-approved weight loss medication that works by blocking the absorption of fat from food. Alli Capsule is taken with meals and snacks that contain fat. It works by blocking the action of an enzyme called lipase, which is responsible for breaking down fat in the digestive system. When lipase is blocked, some of the fat from food is not absorbed into the body and is instead excreted in the stool.
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